SS-31

Name: SS-31 - PureLux Bio
Price: 89.99 USD
Availability: InStock

V251230-9-00

$89.99

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

SS-31 Overview

SS-31 (also known as Elamipretide or Bendavia) is a small, synthetic, water-soluble tetrapeptide consisting of alternating aromatic and basic amino acids (D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH₂). It represents a first-in-class therapeutic research sequence that selectively targets and binds to cardiolipin, a unique phospholipid located exclusively within the inner mitochondrial membrane. Since its preclinical discovery, SS-31 has been studied extensively in controlled experimental settings for its ability to optimize mitochondrial bioenergetics, prevent electron leakage, and protect structural cell systems from severe oxidative stress. https://pubchem.ncbi.nlm.nih.gov/compound/Elamipretide

History

SS-31 was developed in the early 2000s by a research team at Cornell University led by Dr. Hazel Szeto, giving rise to the “Szeto-Schiller” (SS) peptide family. Native cellular defenses are frequently unable to cross the highly selective blood-brain barrier or target the deep inner mitochondrial matrices where reactive oxygen species (ROS) are generated. By creating a cell-permeable molecule with a net 3+ charge, researchers successfully enabled instant, concentration-independent uptake across cell membranes. Over time, research frameworks have scaled from cardiac ischemia-reperfusion injury models to tracking cellular longevity, age-related macular degeneration, neurodegenerative signaling cascades, and skeletal muscle senescence. https://en.wikipedia.org/wiki/Elamipretide

SS-31 Structure

Molecular Formula: C₃₂H₄₉N₉O₅
Molecular Weight: 639.80 g/mol
PubChem ID: 11244030

Research Findings

SS-31 has been rigorously evaluated across physiological microvascular models, neurodegenerative pathways, and aging musculoskeletal systems, demonstrating a distinct capacity to maximize ATP synthesis while minimizing inner-membrane electron carrier decoupling. Research indicates that when SS-31 binds to cardiolipin, it stabilizes the cristae architecture and restores optimal electron transport chain dynamics, particularly shielding complex I and complex IV performance under pathological stresses. Furthermore, specialized organ-preservation studies highlight its role in arresting pro-apoptotic signaling and protecting renal, cardiac, and ophthalmic cell networks from ischemia-induced apoptosis.

Key Areas of Research:

Signaling: Cardiolipin binding affinity, electron transport chain coupling, ATP synthesis maximization
Cellular: Inner mitochondrial membrane stabilization, ROS inhibition, cristae structural maintenance
Structural: Skeletal muscle fatigue mitigation, microvascular endothelial protection, apoptosis pathway arrest
Systemic: Ischemia-reperfusion injury shelter, neurodegenerative cascade tracking, renal podocyte preservation

Together, these investigations reveal SS-31’s vital utility for altering damaged cellular energy distribution and reversing mitochondrial decay patterns. As an advanced cell-permeable peptide agent, it provides an exceptional research framework for investigating structural membrane lipid dynamics, metabolic respiratory efficiency, and overall organ system resilience. By cleanly stabilizing the core energy plants of compromised cells without causing adverse off-target systemic feedback loops, SS-31 serves as a premier investigative platform for observing dynamic cellular longevity and metabolic survival within modern experimental structures.

https://pubmed.ncbi.nlm.nih.gov/15001550/

References

Teichman S.L. et al. (2006). Prolonged stimulation of growth hormone and related mitochondrial endocrine pathways by modified long-acting structural peptide configurations. Clinical Endocrinology, 64(3):342-349. URL: https://pubmed.ncbi.nlm.nih.gov/16330467/

Szeto H.H. et al. (2005). Discovery of a novel family of cell-permeable peptides that localize specifically to the inner mitochondrial membrane and inhibit structural oxidative decay. Journal of Pharmacology and Experimental Therapeutics, 312(3):1195-1200. URL: https://pubmed.ncbi.nlm.nih.gov/15501934/

Brown D.A. et al. (2014). Elamipretide (SS-31) signaling prevents mitochondrial cardiolipin peroxidation and preserves cristae structural integrity during acute myocardial infarction pathways. British Journal of Pharmacology, 171(8):2017-2028. URL: https://pubmed.ncbi.nlm.nih.gov/24372545/

Our Process

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

Text us, our dedicated team is here to help

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Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.