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223460-79-5
Price range: $134.99 through $224.99
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Third-party tested for endotoxins
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid peptide hormone co-secreted with GLP-1 by intestinal endocrine L-cells in response to nutritional ingestion. GLP-2 acts as a potent intestinotrophic factor, specifically regulating growth, tissue maintenance, and barrier functions of the intestinal mucosa. In laboratory settings, GLP-2 is studied for its ability to stimulate crypt cell proliferation, reduce enterocyte apoptosis, enhance nutrient absorption, and inhibit gastric motility.
Following the discovery that proglucagon was processed into multiple bioactive peptides in the 1980s, GLP-2 was identified as a key physiological regulator. In 1996, Daniel Drucker and colleagues demonstrated that GLP-2 administration promoted significant growth of the small intestinal mucosa in mice. This discovery spurred intensive research into the peptide’s therapeutic potential for short bowel syndrome (SBS) and mucosal inflammatory disorders, leading to the design of enzymatically stable synthetic analogues.
GLP-2 has been thoroughly investigated in models of gastrointestinal disease, short bowel syndrome, and epithelial barrier dysfunction. Research shows that GLP-2 binds to its specific G-protein coupled receptor, prompting the release of secondary growth mediators like IGF-1. This signaling pathway accelerates mucosal regeneration, enhances amino acid and hexose transport mechanisms, and decreases mucosal permeability. Preclinical studies also suggest potential anti-inflammatory and cytoprotective properties in models of colitis.
Key Areas of Research:
Intestinal Mucosa: Crypt cell proliferation, villus height elongation, enterocyte survival pathways
Absorption: Nutrient transport upregulation, blood flow facilitation, mucosal barrier restoration
Gastrointestinal: Gastric acid inhibition, transit time optimization, anti-inflammatory cellular signaling
Together, these findings underscore GLP-2’s vital role in intestinal homeostasis. As a specialized intestinotrophic hormone, it provides an exceptional framework for examining epithelial repair mechanisms, secondary growth factor dynamics, and mucosal healing processes within laboratory research.
Drucker D. J. et al. (1996). Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proceedings of the National Academy of Sciences, 93(15):7911-7916. URL: https://pubmed.ncbi.nlm.nih.gov/8755576/
Baggio L. L., Drucker D. J. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology, 132(6):2131-2157. URL: https://pubmed.ncbi.nlm.nih.gov/17498508/
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Precision Lyophilization
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STEP 2
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STEP 3
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