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682809-81-0
$64.99
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Third-party tested for 99% purity, ID, quantity.
Third-party tested for endotoxins
AHK-Cu (Alanyl-Histidyl-Lysine Copper) is a synthetic copper-binding tripeptide complex primarily studied in dermatology and trichology. AHK-Cu is designed to target hair follicle cells, facilitating hair growth and promoting skin rejuvenation. In laboratory models, AHK-Cu is investigated for its capacity to stimulate hair follicle elongation, increase dermal papilla cell viability, and support extracellular matrix components such as collagen and elastin.
The biological activity of copper-peptide complexes was established in the 1970s with GHK-Cu. Seeking cell-specific affinity, researchers synthesized AHK-Cu as a targeted analog focusing on hair follicle physiology. In 2007, researchers at Seoul National University demonstrated its specific stimulatory effects on dermal papilla cells. Since then, AHK-Cu has been explored as a model compound in hair retention research, scalp microcirculation, and advanced cosmetic formulations.
AHK-Cu has been evaluated in trichology and cosmetic dermatology models, showing strong support for hair follicle development and cell survival. Studies indicate that AHK-Cu downregulates apoptosis markers in dermal papilla cells (cleaved caspase-3 and PARP) and raises the Bcl-2/Bax cell-survival ratio. Furthermore, AHK-Cu is associated with increased Vascular Endothelial Growth Factor (VEGF) expression, which may stimulate angiogenesis to enhance microvascular support around active hair follicles.
Key Areas of Research:
Trichology: Hair follicle elongation, dermal papilla cell proliferation, apoptosis mitigation
Vascularization: VEGF pathway activation, angiogenesis induction, follicular micro-blood flow
Dermal Matrix: Fibroblast stimulation, collagen and elastin synthesis, scalp tissue rejuvenation
Together, these investigations highlight AHK-Cu’s specific utility in follicular and scalp biology. By supporting vascular growth factors and suppressing apoptotic pathways in dermal papilla cells, AHK-Cu serves as a premier research platform for studying hair cycle regulation, vascular support mechanisms, and copper-tripeptide pharmacology.
Pyo H. K. et al. (2007). The effect of tripeptide-copper complex on human hair growth in vitro. Archives of Pharmacal Research, 30(7):834-839. URL: https://pubmed.ncbi.nlm.nih.gov/17702555/
Pickart L. et al. (2015). GHK-Cu and regulation of multiple biological processes in aging and repair. BioMed Research International, 2015:648108. URL: https://pubmed.ncbi.nlm.nih.gov/26155344/
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