5-Amino-1MQ

Name: Buy 5-Amino-1MQ | Premium RUO Peptide | 5X Tested | PureLux Bio
SKU: AM
Price: 89.99 USD
Availability: InStock

V251230-9-019

$89.99

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

5-Amino-1MQ Overview

5-Amino-1-MQ (5-Amino-1-methylquinolinium) is a synthetic, small-molecule selective inhibitor of the cytosolic enzyme nicotinamide N-methyltransferase (NNMT). Unlike the majority of therapeutic research sequences, 5-Amino-1-MQ is classified as a low-molecular-weight quinolinium derivative rather than a structurally chained peptide. Since its preclinical profiling, it has been studied extensively in controlled experimental settings for its role in altering cellular energy dynamics, reducing fat accumulation, and investigating the biochemical regulation of the NAD+ salvage pathway. https://pubchem.ncbi.nlm.nih.gov/compound/950107

History

The development of 5-Amino-1-MQ grew out of research exploring cellular target pathways linked directly to metabolic syndrome, type 2 diabetes, and age-related muscle decline. In the search for viable small-molecule therapies, researchers identified NNMT as an enzyme heavily overexpressed in compromised adipose and skeletal muscle tissues. Early experiments isolated 5-Amino-1-MQ as a site-targeting agent capable of curbing lipogenesis and fat tissue expansion without adversely impacting related global methyltransferases. Over time, research frameworks have expanded beyond weight management models into muscle regeneration and cellular longevity dynamics. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021245

5-Amino-1MQ Structure

V251230-9-019
Molecular Formula: C₁₀H₁₁N₂⁺ (C₁₀H₁₁IN₂ in its highly stable iodide salt configuration)
Molecular Weight: 159.21 g/mol (Cation base) / 286.11 g/mol (Iodide salt form)
PubChem ID: 950107 (Parent Cation) / 66522933 (Iodide Salt)

Research Findings

5-Amino-1-MQ has been comprehensively evaluated across metabolic, structural, and physiological aging models, demonstrating unique activity in blocking NNMT pathways, elevating intracellular NAD+ availability, and preserving sirtuin-1 signaling dynamics. Studies evaluate its direct capacity to accelerate fat loss, decrease tissue adiposity, and improve hepatic steatosis baseline vectors in animal models under high-fat dietary conditions. Furthermore, research notes its critical role in stimulating muscle stem cells to enhance functional tissue repair mechanisms.

Key Areas of Research:

Signaling: NNMT enzyme inhibition, NAD+ salvage regulation, sirtuin-1 pathway preservation
Metabolic: Lipogenesis reduction, intracellular adipocyte modification, energy expenditure regulation
Structural: Muscle stem cell (muSC) differentiation, functional tissue proliferation, myogenesis acceleration
Systemic: Hepatic steatosis correction tracking, insulin sensitivity dynamics, metabolic resilience mapping

Together, these investigations reveal 5-Amino-1-MQ’s profound ability to alter tissue-specific metabolic adaptation via enzyme pathway modulation. As a non-peptide small molecule, it provides a highly reliable biochemical foundation for analyzing the intricate interplay between cellular methylation balance, fat deposition, and functional performance limits. By blocking systemic metabolic brakes, 5-Amino-1-MQ delivers a distinct and versatile framework for probing energetic cellular resilience within experimental boundaries. https://www.sciencedirect.com/science/article/pii/S000629521830138X

References

Neelakantan H. et al. (2018). Small molecule nicotinamide N-methyltransferase inhibitor activates senescent cutaneous cells and accelerates wound healing. Biochemical Pharmacology, 147:141-152. URL: https://pubmed.ncbi.nlm.nih.gov/29672274/

Neelakantan H. et al. (2019). Nicotinamide N-methyltransferase inhibition reverses diet-induced obesity in mice. Molecular Metabolism, 21:12-23. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021245/

Brightwell C.R. et al. (2022). NNMT inhibition boosts senescent muscle stem cell activation and enhances physical performance during sarcopenia. Journals of Gerontology Series A, 77(11):2155-2164. URL: https://pubmed.ncbi.nlm.nih.gov/35325121/

Our Process

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

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Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.