GLP-1

106612-94-6

Price range: $84.99 through $144.99

Available Configurations

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

GLP-1 Overview

Glucagon-like peptide-1 (GLP-1) is an endogenous 31-amino-acid incretin peptide hormone secreted by intestinal L-cells in response to food intake. It plays a critical role in glucose homeostasis and appetite regulation. In preclinical and laboratory settings, GLP-1 is studied for its ability to stimulate glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and promote satiety via central nervous system receptor activation.

https://pubchem.ncbi.nlm.nih.gov/compound/16133830

History

GLP-1 was discovered in the 1980s following cloning of the preproglucagon gene, with Svetana Mojsov identifying GLP-1 (7-37) as the active insulinotropic peptide in 1986. Further physiological studies established its incretin role in humans. Due to its rapid degradation by dipeptidyl peptidase-4 (DPP-4), subsequent research focused on developing stable, long-acting synthetic receptor agonists (such as liraglutide and semaglutide) to study sustained endocrine and metabolic pathways.

https://en.wikipedia.org/wiki/Glucagon-like_peptide-1

GLP-1 Structure

Molecular Formula: C₁₅₁H₂₂₈N₄₀O₄₇
Molecular Weight: 3355.7 g/mol
PubChem ID: 16133830

Research Findings

GLP-1 has been rigorously evaluated in laboratory models of glycemic regulation, satiety control, and cellular cytoprotection. Studies highlight its role in activating adenylate cyclase to increase cyclic AMP (cAMP) levels, stimulating insulin release exclusively in the presence of elevated glucose, and promoting beta-cell viability. Additional research indicates potential neuroprotective, anti-inflammatory, and cardiovascular protective signaling cascades in experimental models.

Key Areas of Research:

Endocrine: Glucose-dependent insulin upregulation, beta-cell signaling, glucagon pathway inhibition
Satiety: Central receptor binding, appetite regulation, gastric emptying delay kinetics
Cardiovascular: Endothelial protection, blood flow dynamics, anti-inflammatory receptor signaling

Together, these investigations reveal GLP-1’s central role in homeostatic endocrine feedback loops. By safely balancing glucose levels and suppressing intake signals without inducing hypoglycemic states, GLP-1 serves as a fundamental platform for research into incretin pharmacology, pancreatic health, and metabolic pathways.

https://pubmed.ncbi.nlm.nih.gov/16330467/

References

Mojsov S. et al. (1986). Preproglucagon gene expression in pancreas and intestine at the level of posttranslational processing. Journal of Biological Chemistry, 261(25):11880-11889. URL: https://pubmed.ncbi.nlm.nih.gov/3528148/

Kreymann B. et al. (1987). Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet, 2(8571):1300-1304. URL: https://pubmed.ncbi.nlm.nih.gov/2890903/

Our Process

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

Text us, our dedicated team is here to help

Reach out and get a response within minutes.

Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.